Tobacco grows very well indoors and in a hydro system. Advanced Garden has been growing the same tobacco plant for over two years now, taking clones is easy and they always start in about 2 weeks or less.
We harvest the leaves and dry and cure them being carefull not to let them mold.
The Tobacco is in our Ebb & Flow table and although we keep the PPM low most of the time it seems to be able to take quite a strong solution.
A few times the pump was not working and the Tabacco had wilted but it allways bounced right back after a little drink.
Here is a link to a pdf with some specialized instructions for curing your own Tobacco.